H O R M O N E

Pituitary disorders - impact of the master gland

Understanding

Understanding the function of the human body is never a cakewalk; many cells, enzymes, hormones, etc. are involved to carry out one function in the body. Most of these functions are regulated by hormones, and the concentration of most hormones is controlled by the master gland – the pituitary gland. So, if any abnormalities occur in the hormone levels, your pituitary gland may be involved.

How important is the pituitary gland?

Weighing less than one gram and situated below the brain in the skull base is your master gland “the pituitary gland”. The glandsecretes hormones for controlling various functions of the body and also regulates many other glands such as adrenal, thyroid and reproductive.

What hormones are produced by the pituitary gland?

The pituitary gland produces various hormones including:

  • Growth Hormone: It regulates body and brain development, bone maturation, metabolism and is important for healthy muscles.

  • Luteinizing Hormone and Follicle Stimulating Hormone: These hormones control the production of estrogen and testosterone as well as maturation and release of sperm and egg.

  • Prolactin: It stimulates secretion of breast milk.

  • Thyroid Stimulating Hormone: It stimulates the thyroid gland to release thyroid hormones.

  • Adrenocorticotropic Hormone: It triggers the adrenal glands (situated above the kidneys) to release the hormone cortisol which in turn, regulates carbohydrate, fat, and protein metabolism and is important in the stress response.

  • Vasopressin (anti-diuretic hormone): It promotes water to be reabsorbed by the kidneys and maintains balance of water and electrolyte in the body.

What can cause a dysfunctional pituitary gland?

The cells of the pituitary gland may divide uncontrollably and form benign tumor (non-cancerous growth). The gland will then produce too much of hormone. Other tumors of the pituitarygland can become large and cause compression of the gland leading to decreased or no hormone production. Damage to the pituitary gland can also be due to various other conditions including:

  • Radiation

  • Surgery

  • Infections such meningitis

What happens when something goes wrong with the pituitary gland?

Hormones released by the pituitary gland have broad range of effects on growth and development, sexuality and reproductive function, metabolism, response to stress and quality of life. The health problemsthat may arise due to a dysfunctional pituitarygland are as follows:

  • In acromegaly, Cushing disease, the pituitary gland produces too much of one or more hormone.

  • In adult-onset growth hormone deficiency, diabetes insipidus, the pituitarygland produces less amount of one or more hormones.

What happens to an individual when the pituitarygland is underactive?

The effect of an underactive pituitary glanddepends on which hormones the pituitary gland is not producing. For example, if the gland does not produce enough growth hormone in a child, they may have a permanent short stature, if it does not produce enough follicle stimulating hormone or luteinizing hormone, it might cause problems with sexual function, menstruation and fertility.

How are pituitary disorders detected?

Blood tests and urine tests are the primary tests used to know the hormone levels in the body, if a pituitary tumor is suspected from the results of tests, then it is confirmed by imaging tests such as MRI (magnetic resonance imaging) or CT (computerized tomography) scan, to examine the pituitary gland and the surrounding parts of thebrain.

Can a pituitary tumor spread to other parts of the body?

The pituitary tumors are benign glandular tumors called pituitary adenomas. They grow very slowly and sometimes they grow into the bony walls of sella turcica (bony depression which contains pituitary gland) and nearby tissues, like blood vessels, nerves and sinuses leading to problems like vision changes or headaches. Rarely, the large tumor spreads to other parts of the body.

How does a person develop Diabetes insipidus?

Diabetes insipidus is a rare disease that develops when damage to the pituitary gland disrupts the normal production of hormone vasopressin, which helps control the volume of water in the body. As a result, kidneys remove too much fluid from the body in the form of increased urine. In severe cases, a person may pass upto 30 liters of urine per day. Diabetes insipidus may cause dehydration and eventually coma due to loss of electrolytes in urine.

Why is the pituitary gland called the master gland?

The pituitary gland is called the master gland as it controls the activity of most other major endocrine glands such as the thyroid gland, ovaries and testis and the adrenal gland.